The human organic cation transporter 2 (hOCT2) transports cadmium (Cd 2+ ) and mediates Cd 2+ induced cell death

The CD 3 ~ " Cytoplasmic Domain Mediates CD 2 - induced T Cell . Activation

CD2-mediated T lymphocyte activation requires surface expression of CD3-Ti, the T cell receptor (TCR) for antigen major histocompatibility complex protein. Given the importance of CD3~" in TCR signaling, we have directly examined the ability of the CD3~" cytoplasmic domain to couple CD2 to intracellular signal transduction pathways. A cDNA encoding a chimeric protein consisting of the human CD3...

The biological characteristics of CD 34 + CD 2 + adult acute promyelocytic leukemia and the CD 34 – CD 2

Acute promyelocytic leukemia (APL) is an acute myeloid leukemia characterized by leukemic cells blocked at the promyelocytic stage of granulocytic differentiation. According to the FrenchAmerican-British (FAB) classification, two main cytological subtypes are recognized: (i) classical hypergranular promyelocytic leukemia (M3) and (ii) the microgranular promyelocytic leukemia variant (M3v). Rece...

Interaction of Cisplatin with the human organic cation transporter 2.

PURPOSE Cisplatin is predominantly eliminated in the urine through active secretion. As the solute carrier organic cation transporter 2 (OCT2) is highly expressed in the basolateral membrane of proximal tubules, we determined its contribution to cisplatin transport and assessed the relation of variation in the gene encoding OCT2 (SLC22A2) with the disposition of cisplatin. EXPERIMENTAL DESIGN...

Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 (hOCT2) and Multidrug and Toxin Extrusion Proteins (hMATEs)

Ther A B CD 2

ownloade short circulating half-life and side effects of IFNα affect its dosing schedule and efficacy. Fusion of IFNα mor-targeting monoclonal antibody (MAb-IFNα) can enhance potency due to increased tumor localiand improved pharmacokinetics. We report the generation and characterization of the first bispecific FNα, designated 20-C2-2b, which comprises two copies of IFNα2b and a stabilized F(ab...